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1

Synthesis of 2-Keto-imidazoles Utilizing N -Arylamino-Substituted N-Heterocyclic Carbenes

Zarganes-Tzitzikas, Tryfon, Neochoritis, Constantinos G., Stephanidou-Stephanatou, Julia, Tsoleridis, Constantinos A.

Journal:

Journal of Organic Chemistry

Year:

2011

Language:

english

File:

PDF, 1.16 MB

english, 2011

2

[Annual Reports in Medicinal Chemistry] Volume 49 || p53–MDM2 and MDMX Antagonists

Neochoritis, Constantinos

Year:

2014

Language:

english

File:

PDF, 1.10 MB

english, 2014

3

The Leuckart-Wallach Route Towards Isocyanides and Some Applications

Neochoritis, Constantinos G., Zarganes-Tzitzikas, Tryfon, Stotani, Silvia, Dömling, Adrian, Herdtweck, Eberhardt, Khoury, Kareem, Dömling, Alexander

Journal:

ACS Combinatorial Science

Year:

2015

Language:

english

File:

PDF, 878 KB

english, 2015

4

Artificial macrocycles as potent p53-MDM2 inhibitors

Estrada-Ortiz, Natalia, Neochoritis, Constantinos G., Twarda-Clapa, Aleksandra, Musielak, Bogdan, Holak, Tad A, Dömling, Alexander

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 702 KB

english, 2017

5

Application of Silver Nanoparticles in the Multicomponent Reaction Domain: A Combined Catalytic Reduction Methodology to Efficiently Access Potential Hypertension or Inflammation Inhibitors

Iordanidou, Domna, Zarganes-Tzitzikas, Tryfon, Neochoritis, Constantinos G., Dömling, Alexander, Lykakis, Ioannis N.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.59 MB

english, 2018

6

Tetrazoles via Multicomponent Reactions

Neochoritis, Constantinos G., Zhao, Ting, Dömling, Alexander

Journal:

Chemical Reviews

Year:

2019

Language:

english

File:

PDF, 27.05 MB

english, 2019

7

Multicomponent Peptide Stapling as a Diversity‐Driven Tool for the Development of Inhibitors of Protein‐Protein Interactions

Doemling, Alexander, Ricardo, Manuel, Ali, Ameena, Plewka, Jacek, Surmiak, Ewa, Labuzek, Beata, Neochoritis, Constantinos, Atmaj, Jack, Skalniak, Lukasz, Zhang, Ran, Holak, Tad, Groves, Matthew, River

Journal:

Angewandte Chemie

Year:

2020

Language:

english

File:

PDF, 1.49 MB

english, 2020

8

Multicomponent Reactions: âKinderleichtâ

Neochoritis, Constantinos G., Zarganes-Tzitzikas, Tryfon, Katsampoxaki-Hodgetts, Kallia, DÃ¶mling, Alexander

Journal:

Journal of Chemical Education

Year:

2020

File:

PDF, 6.24 MB

2020

9

ChemInform Abstract: One-Pot Microwave Assisted Synthesis under Green Chemistry Conditions, Antioxidant Screening, and Cytotoxicity Assessments of Benzimidazole Schiff Bases and Pyrimido[1,2-a]benzimidazol-3(4H)-ones.

Constantinos G. Neochoritis, Tryfon Zarganes-Tzitzikas, Constantinos A. Tsoleridis, Julia Stephanidou-Stephanatou, Christos A. Kontogiorgis, Dimitra J. Hadjipavlou-Litina, Theodora Choli-Papadopoulou

Journal:

Year:

2011

Language:

english

File:

PDF, 39 KB

english, 2011

10

ChemInform Abstract: Synthesis of 2-Keto-imidazoles Utilizing N-Arylamino-Substituted N-Heterocyclic Carbenes.

Tryfon Zarganes-Tzitzikas, Constantinos G. Neochoritis, Julia Stephanidou-Stephanatou, Constantinos A. Tsoleridis

Journal:

Year:

2011

File:

PDF, 31 KB

2011

11

ChemInform Abstract: One-Pot Regioselective Double-Mannich Annulations Affording Azabicyclononanones as a Key Step in the Synthesis of Natural Products.

Constantinos G. Neochoritis, Julia Stephanidou-Stephanatou, Constantinos A. Tsoleridis

Journal:

Year:

2012

File:

PDF, 33 KB

2012

12

One-Pot Regioselective Double-Mannich Annulations Affording Azabicyclononanones as a Key Step in the Synthesis of Natural Products

Constantinos G. Neochoritis, Julia Stephanidou-Stephanatou, Constantinos A. Tsoleridis

Journal:

European Journal of Organic Chemistry

Year:

2011

Language:

english

File:

PDF, 458 KB

english, 2011

13

One-pot microwave assisted synthesis under green chemistry conditions, antioxidant screening, and cytotoxicity assessments of benzimidazole Schiff bases and pyrimido[1,2-a]benzimidazol-3(4H)-ones

Constantinos G. Neochoritis, Tryfon Zarganes-Tzitzikas, Constantinos A. Tsoleridis, Julia Stephanidou-Stephanatou, Christos A. Kontogiorgis, Dimitra J. Hadjipavlou-Litina, Theodora Choli-Papadopoulou

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 527 KB

english, 2011

14

1-Arylaminoimidazole-2-thiones as intermediates in the synthesis of imidazo[2,1-b][1,3,4]thiadiazines

Constantinos Neochoritis, Constantinos A. Tsoleridis, Julia Stephanidou-Stephanatou

Journal:

Year:

2008

Language:

english

File:

PDF, 290 KB

english, 2008

15

A thorough study on the reaction of DMAD with 1-arylaminoimidazole-2-thiones. Expeditious synthesis of imidazo[2,1-b][1,3]thiazoles through a novel arylamino rearrangement

Constantinos Neochoritis, Nicolaos Eleftheriadis, Constantinos A. Tsoleridis, Julia Stephanidou-Stephanatou

Journal:

Year:

2010

Language:

english

File:

PDF, 465 KB

english, 2010

16

The first application of an imidazole o-quinodimethane in Diels–Alder reactions leading to the synthesis of benzimidazoles

Constantinos Neochoritis, Despina Livadiotou, Julia Stephanidou-Stephanatou, Constantinos A. Tsoleridis

Journal:

Tetrahedron Letters

Year:

2007

Language:

english

File:

PDF, 115 KB

english, 2007

17

Azodicarboxylates: valuable reagents for the multicomponent synthesis of novel 1,3,4-thiadiazoles and imidazo[2,1-b][1,3,4]thiadiazoles

Zarganes-Tzitzikas, Tryfon, Neochoritis, Constantinos G., Stephanidou-Stephanatou, Julia, Tsoleridis, Constantinos A., Buth, Gernot, Kostakis, George E.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.07 MB

english, 2013

18

One-pot microwave assisted synthesis of new 2-alkoxycarbonylmethylene-4-oxo-1,5-benzo-, naphtho-, and pyridodiazepines and assessment of their cytogenetic activity

Eleftheriadis, Nicolaos, Neochoritis, Constantinos G., Tsoleridis, Constantinos A., Stephanidou-Stephanatou, Julia, Iakovidou-Kritsi, Zafiroula

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 862 KB

english, 2013

19

1,5-Benzoxazepines vs 1,5-Benzodiazepines. One-Pot Microwave-Assisted Synthesis and Evaluation for Antioxidant Activity and Lipid Peroxidation Inhibition

Neochoritis, Constantinos G., Tsoleridis, Constantinos A., Stephanidou-Stephanatou, Julia, Kontogiorgis, Christos A., Hadjipavlou-Litina, Dimitra J.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.61 MB

english, 2010

20

Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions

Neochoritis, Constantinos G., Dömling, Alexander

Journal:

Organic & Biomolecular Chemistry

Year:

2014

Language:

english

File:

PDF, 709 KB

english, 2014

21

Dimethyl Acetylenedicarboxylate: A Versatile Tool in Organic Synthesis

Neochoritis, Constantinos, Zarganes-Tzitzikas, Tryfon, Stephanidou-Stephanatou, Julia

Journal:

Year:

2014

Language:

english

File:

PDF, 1.01 MB

english, 2014

22

Efficient Isocyanide-less Isocyanide-Based Multicomponent Reactions

C. G. Neochoritis, S. Stotani, B. Mishra, A. Dömling

Year:

2015

Language:

english

File:

PDF, 718 KB

english, 2015

23

Efficient Isocyanide-less Isocyanide-Based Multicomponent Reactions

Neochoritis, Constantinos G., Stotani, Silvia, Mishra, Bhupendra, Dömling, Alexander

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 718 KB

english, 2015

24

One-Pot DBU-Promoted Synthesis of Hydroacridinones and Spirohexahydropyrimidines

Neochoritis, Constantinos, Eleftheriadis, Nicolaos, Tsiantou, Arianna, Stephanidou-Stephanatou, Julia, Tsoleridis, Constantinos

Journal:

Year:

2013

Language:

english

File:

PDF, 224 KB

english, 2013

25

Heterocyclizations via TosMIC-Based Multicomponent Reactions: A New Approach to One-Pot Facile Synthesis of Substituted Quinoxaline Derivatives

Neochoritis, Constantinos, Stephanidou-Stephanatou, Julia, Tsoleridis, Constantinos

Journal:

Year:

2009

Language:

english

File:

PDF, 83 KB

english, 2009

26

Rational development of a potent 15-lipoxygenase-1 inhibitor with in vitro and ex vivo anti-inflammatory properties

N. Eleftheriadis, C. Neochoritis, N. Leus, P. Van Der Wouden, A. Dömling, F. J. Dekker

Year:

2015

Language:

english

File:

PDF, 1.38 MB

english, 2015

27

A Versatile One-Pot Synthesis of β-Carbolines by Reaction of Pyranoindolones with Phenyl- and Benzoylhydrazine

Livadiotou, Despina, Hatzimimikou, Dimitra, Neochoritis, Constantinos, Terzidis, Michael, Tsoleridis, Constantinos, Stephanidou-Stephanatou, Julia

Journal:

Year:

2008

Language:

english

File:

PDF, 130 KB

english, 2008

28

A Versatile One-Pot Synthesis of Fused Polycyclic Imidazole-naphthoquinone Derivatives through Imidazole-4,5-quinodimethane Generation Followed by Diels-Alder Cycloaddition

Neochoritis, Constantinos, Stephanidou-Stephanatou, Julia, Tsoleridis, Constantinos

Journal:

Year:

2007

Language:

english

File:

PDF, 62 KB

english, 2007

29

Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

Liao, George P., Abdelraheem, Eman M. M., Neochoritis, Constantinos G., Kurpiewska, Katarzyna, Kalinowska-Tłuścik, Justyna, McGowan, David C., Dömling, Alexander

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 1.65 MB

english, 2015

30

Leuckart–Wallach Approach to Sugar Isocyanides and Its IMCRs

Neochoritis, Constantinos, Zhang, Ji, Dömling, Alexander

Journal:

Year:

2015

Language:

english

File:

PDF, 333 KB

english, 2015

31

Unexpected Opening of the Benzodiazepine Ring During Acetylation

Tsoleridis, Constantinos, Neochoritis, Constantinos, Pozarentzi, Minodora, Stephanidou-Stephanatou, Julia

Journal:

Letters in Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 146 KB

english, 2008

32

2,3′-Bis(1′H-indole) heterocycles: New p53/MDM2/MDMX antagonists

Neochoritis, Constantinos G., Wang, Kan, Estrada-Ortiz, Natalia, Herdtweck, Eberhardt, Kubica, Katarzyna, Twarda, Aleksandra, Zak, Krzysztof M., Holak, Tad A., Dömling, Alexander

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.42 MB

english, 2015

33

First catalytic hetero-Diels–Alder reaction of imidazole-2-thiones and in silico biological evaluation of the cycloadducts

Eleftheriadis, Nikolaos, Samatidou, Evanthia, Neochoritis, Constantinos G.

Journal:

Year:

2016

Language:

english

File:

PDF, 884 KB

english, 2016

34

ChemInform Abstract: Azodicarboxylates: Valuable Reagents for the Multicomponent Synthesis of Novel 1,3,4-Thiadiazoles and Imidazo[2,1-b][1,3,4]thiadiazoles.

Zarganes-Tzitzikas, Tryfon, Neochoritis, Constantinos G., Stephanidou-Stephanatou, Julia, Tsoleridis, Constantinos A., Buth, Gernot, Kostakis, George E.

Journal:

Year:

2013

File:

PDF, 26 KB

2013

35

ChemInform Abstract: Towards a Facile and Convenient Synthesis of Highly Functionalized Indole Derivatives Based on Multi-Component Reactions.

Neochoritis, Constantinos G., Doemling, Alexander

Journal:

Year:

2014

File:

PDF, 29 KB

2014

36

ChemInform Abstract: Dimethyl Acetylenedicarboxylate: A Versatile Tool in Organic Synthesis

Neochoritis, Constantinos G., Zarganes-Tzitzikas, Tryfon, Stephanidou-Stephanatou, Julia

Journal:

Year:

2014

File:

PDF, 12 KB

2014

37

ChemInform Abstract: Efficient Isocyanide-Less Isocyanide-Based Multicomponent Reactions.

Neochoritis, Constantinos G., Stotani, Silvia, Mishra, Bhupendra, Doemling, Alexander

Journal:

Year:

2015

File:

PDF, 12 KB

2015

38

How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures

Estrada-Ortiz, Natalia, Neochoritis, Constantinos G., Dömling, Alexander

Journal:

Year:

2016

Language:

english

File:

PDF, 6.67 MB

english, 2016

39

ChemInform Abstract: One-Pot DBU-Promoted Synthesis of Hydroacridinones and Spirohexahydropyrimidines.

Neochoritis, Constantinos G., Eleftheriadis, Nicolaos, Tsiantou, Arianna, Stephanidou-Stephanatou, Julia, Tsoleridis, Constantinos A.

Journal:

Year:

2014

File:

PDF, 27 KB

2014

40

Isocyanides as Influenza A Virus Subtype H5N1 Wild-Type M2 Channel Inhibitors

Wu, Shuwen, Huang, Jing, Gazzarrini, Sabrina, He, Si, Chen, Lihua, Li, Jun, Xing, Li, Li, Chufang, Chen, Ling, Neochoritis, Constantinos G., Liao, George P., Zhou, Haibing, Dömling, Alexander, Moroni,

Journal:

Year:

2015

Language:

english

File:

PDF, 1.91 MB

english, 2015

41

ChemInform Abstract: One-Pot Microwave Assisted Synthesis of New 2-Alkoxycarbonylmethylene-4-oxo-1,5-benzo-, naphtho-, and pyridodiazepines and Assessment of Their Cytogenetic Activity.

Eleftheriadis, Nicolaos, Neochoritis, Constantinos G., Tsoleridis, Constantinos A., Stephanidou-Stephanatou, Julia, Iakovidou-Kritsi, Zafiroula

Journal:

Year:

2014

File:

PDF, 25 KB

2014

42

ChemInform Abstract: First Catalytic Hetero-Diels-Alder Reaction of Imidazole-2-thiones and in silico Biological Evaluation of the Cycloadducts.

Eleftheriadis, Nikolaos, Samatidou, Evanthia, Neochoritis, Constantinos G.

Journal:

Year:

2016

File:

PDF, 28 KB

2016

43

The indoleacetic acids in IMCRs: a three-component Ugi reaction involving TosMIC

Neochoritis, Constantinos G., Livadiotou, Despina, Tsiaras, Vassilios, Zarganes-Tzitzikas, Tryfon, Samatidou, Evanthia

Journal:

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

44

Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties

Eleftheriadis, Nikolaos, Poelman, Hessel, Leus, Niek G.J., Honrath, Birgit, Neochoritis, Constantinos G., Dolga, Amalia, Dömling, Alexander, Dekker, Frank J.

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.94 MB

english, 2016

45

One-pot reaction of pyranoindolones with phenylisocyanates: A simple and regioselective approach to β-carbolines

Livadiotou, Despina, Hatzimimikou, Dimitra, Tsitsi, Dimitra, Tsiaras, Vassilios, Samatidou, Evanthia, Neochoritis, Constantinos G.

Journal:

Tetrahedron Letters

Year:

2016

Language:

english

File:

PDF, 941 KB

english, 2016

46

Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction

Surmiak, Ewa, Neochoritis, Constantinos G., Musielak, Bogdan, Twarda-Clapa, Aleksandra, Kurpiewska, Katarzyna, Dubin, Grzegorz, Camacho, Carlos, Holak, Tad A., Dömling, Alexander

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.98 MB

english, 2016

47

Scaffold hopping via ANCHOR.QUERY: β-lactams as potent p53-MDM2 antagonists

Shaabani, S., Neochoritis, C. G., Twarda-Clapa, A., Musielak, B., Holak, T. A., Dömling, A.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.45 MB

english, 2017

48

1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers

Twarda-Clapa, Aleksandra, Krzanik, Sylwia, Kubica, Katarzyna, Guzik, Katarzyna, Labuzek, Beata, Neochoritis, Constantinos G., Khoury, Kareem, Kowalska, Kaja, Czub, Miroslawa, Dubin, Grzegorz, Dömling,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.74 MB

english, 2017

49

Manipulating a Multicomponent Reaction: A Straightforward Approach to Chromenopyrazole Hybrid Scaffolds

Kasapidou, Paraskevi, Zarganes-Tzitzikas, Tryfon, Tsoleridis, Constantinos, Stephanidou-Stephanatou, Julia, Neochoritis, Constantinos

Journal:

Year:

2017

Language:

english

File:

PDF, 305 KB

english, 2017

50

Discovery of chromenes as inhibitors of macrophage migration inhibitory factor

Kok, Tjie, Wapenaar, Hannah, Wang, Kan, Neochoritis, Constantinos G., Zarganes-Tzitzikas, Tryfon, Proietti, Giordano, Eleftheriadis, Nikolaos, Kurpiewska, Katarzyna, Kalinowska-Tłuścik, Justyna, Cool,

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 558 KB

english, 2017